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Here we are, just a year after the first news of the coronavirus we now call SARS-CoV-2 and the global pandemic known as COVID-19…and scientists have already developed more than one safe and effective vaccine. How could they do this so quickly? I visited the lab whose work directly led to these first COVID vaccines, so you can learn about the connection between basic research and life-saving medicine. Here's how to make a COVID-19 vaccine.
Coronavirus animation, courtesy of: Janet Iwasa, University of Utah, with funding from the NSF, the Coronavirus Structural Working Group, and the German Federal Ministry of Research.
The references:
Wrapp, D. et al. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science 367, 1260-1263 (2020) doi: 10.1126/science.abb2507
Watanabe, Y., Allen, J.D., Wrapp, D., McLellan, J.S., and Crispin, M. SARS-CoV-2 spike site-specific glycan analysis. Science eabb9983 (2020) doi:10.1126/science.abb9983.
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